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Background: Intussusception being the leading cause of acute abdomen in childhood, its timely and accurate diagnosis assumes utmost significance in reducing the morbidity and mortality. Childhood intussusceptions are still managed surgically in our region; however, non-operative reduction has now become the gold standard of treatment worldwide. In this study, authors desired to evaluate the suitability and effectiveness of hydrostatic reduction of intussusception under ultrasound (USG)-guidance and to scrutinize the factors affecting the successful outcome.Methods: Ours was a prospective study carried out at a tertiary care centre in central Kashmir. All except those with clinical features of bowel gangrene, intestinal prolapse and peritonitis underwent ultrasound-guided hydrostatic reduction (USGHR). A maximum of three attempts were allowed.Results: Mean age of the patients was 11.2±8.8 months with age range of 3-50 months. 69.1% (n=38) of the patients presented within 24 h of being symptomatic while 30.9% had delayed presentation (>24 h). The success rate of USGHR was 81.8% (n=45). Late presentation, age and gender of the patients had no influence on successful outcome of the procedure, p >0.005. The duration of hospital stay between those who had successful hydrostatic reduction and those who afterwards underwent operative reduction or resection achieved statistical significance, p=0.0015. Authors attained a 66.2 % (45/68) reduction in operative management using USGHR as the main modality of treatment.Conclusions: USGHR is a simple, safe and effective non-operative method of treating intussusceptions in children in a limited resource setting.
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Background: In view of the fact that Brightness (B)-mode ultrasound findings in patients with renal parenchymal disease are profoundly non-specific, this study was carried out to determine the efficiency of color Doppler sonography for assessing renal function. In this series, the relationship between the resistive index (RI) of renal interlobar artery and serum creatinine level was analyzed for any relevant association of this color Doppler index with the serum creatinine level.Methods: In this prospective cross-sectional study, 40 patients with renal parenchymal disease having serum creatinine level >1.4 mg/dL were chosen midst routine revisits. The control group comprised of 40 normal subjects with serum creatinine levels <1.4 mg/dL. After assessing the kidneys of these subjects with gray-scale ultrasound for presence of any stones, hydronephrosis, and/or space occupying lesions instead of, they were subsequently interrogated with color Doppler sonography and RI calculated.Results: The mean serum creatinine levels±SD in the case and control groups were 6.7±0.7 mg/dL and 1.0±0.4 mg/dL, respectively. The mean±SD resistive index (RI) was 79.0%±1.8% in the diseased group and 60.3%±0.7% in the healthy subjects (p<0.001). The correlation between the RI and the serum creatinine level was statistically significant (p<0.001).Conclusions: Resistive index (RI) measurement by color doppler ultrasonography is a reasonable prognosticator of functional outcome in patients with renal parenchymal disease.
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OBJECTIVE: The usual seminal profile has been customarily used for diagnosing male infertility based on an examination of semen samples. However, sperm DNA fragmentation has also been causally linked to reproductive failure, suggesting that it should be evaluated as part of male infertility assessments. To compare the ability of the five most widely utilized methodologies of measuring DNA fragmentation to predict male infertility and reactive oxygen species by Oxisperm kit assay. METHODS: In this case-control study, which received ethical committee approval, the participants were divided into fertile and infertile groups (50 patients in each group). RESULTS: The alkaline comet test showed the best ability to predict male infertility, followed by the terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay, the sperm chromatin dispersion (SCD) test, and the sperm chromatin structure assay (SCSA), while the neutral comet test had no predictive power. For our patient population, the projected cut-off point for the DNA fragmentation index was 22.08% using the TUNEL assay, 19.90% using SCSA, 24.74% using the SCD test, 48.47% using the alkaline comet test, and 36.37% using the neutral comet test. Significant correlations were found between the results of the SCD test and those obtained using SCSA and TUNEL (r =0.70 and r =0.68, respectively; p<0.001), and a statistically significant correlation was also found between the results of SCSA and the TUNEL assay (r =0.77, p<0.001). Likewise, the results of the alkaline comet test showed significant correlations with those of the SCD, SCSA, and TUNEL tests (r =0.59, r =0.57, and r =0.72, respectively; p<0.001). CONCLUSION: The TUNEL assay, SCSA, SCD, and the alkaline comet test were effective for distinguishing between fertile and infertile patients, and the alkaline comet test was the best predictor of male infertility.
Subject(s)
Humans , Male , Male , Case-Control Studies , Chromatin , DNA Fragmentation , DNA Nucleotidylexotransferase , DNA , In Situ Nick-End Labeling , Infertility , Infertility, Male , Methods , Reactive Oxygen Species , Semen , Sensitivity and Specificity , SpermatozoaABSTRACT
OBJECTIVE: The male reproductive system generates, accumulates, and transports the sperm. In this study, 2 methods of surgically retrieving sperm, namely, testicular sperm aspiration (TESA) and percutaneous epididymal sperm aspiration (PESA), are discussed and studied in men aged ≤38 years to achieve successful conception using assisted reproductive technology. The purpose was to assess the fertilization rate (FA), clinical pregnancy, and live birth rate (LBR) with sperm. METHODS: A total of 287 semen samples were divided into 4 groups as follows: fresh PESA (n=73), frozen PESA (n=65), fresh TESA (n=128), and frozen TESA (n=21). The DNA fragmentation test using sperm chromatin dispersion assay was measured and reported. RESULTS: FA was 70.3% and 65.5%, (P<0.022) for fresh and frozen epididymal sperm and 53.8% and 49.5%, (P<0.032) for fresh and frozen testicular sperm. LBR was 33.6% and 30.2% (P<0.075) for fresh and frozen epididymal sperm (PESA) and 22.7% and 18.2% (P<0.063) for fresh and frozen-thawed TESA sperm. CONCLUSION: Exposure to tissue shearing may adversely affect sperm quality. Increased sperm DNA damage due to long-term exposure while teasing enhances reactive oxygen species production foremost to membrane damage because of the oxidation of polyunsaturated fatty acid in lipids (lipid peroxidation), oxidation of amino acid in proteins, and inactivation of specific enzymes, all leading to enzymatic dipping and possibility of less fertilization and conception as indicated by the increase in LBR with fresh/frozen PESA compared to with fresh/frozen TESA.
Subject(s)
Humans , Male , Pregnancy , Chromatin , DNA Damage , DNA Fragmentation , Fertilization , Infertility , Live Birth , Membranes , Reactive Oxygen Species , Reproductive Techniques, Assisted , Retrospective Studies , Semen , Sperm Injections, Intracytoplasmic , Sperm Retrieval , SpermatozoaABSTRACT
The purpose of this corrigendum is to publish the corrections in the article.
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Background: Pneumatisation of various bones around the nasal cavity results in the formation of paranasal sinuses. Varying degrees of pneumatisation result in multiple variations of paranasal sinuses some of which are important from clinical, pathological and surgical perspective. Objective: Determining the prevalence of various sinonasal anatomical variations on multi-detector computed tomography. Materials and methods: 852 patients with various symptoms of active rhinosinusitis were subjected to non-contrast enhanced CT examinations of the paranasal sinuses and nasal cavity. Multi-planar reconstructions were done in axial, coronal and sagittal plane and the reconstructed CT images were evaluated for the presence of anatomic variants of the sinonasal cavities and the prevalence of each variant was calculated. Results: Deviated nasal septum (DNS) was the most common anatomic variant of the paranasal sinuses and nasal cavity seen in 724 patients (85%), if minimal septal deviation (<1 mm) was also taken into account. The second most common variant was prominent ethmoid bulla which was present in 392 of 852 patients (46%). Dehiscent lamina papyracea (0.9%) and pneumatised crista galli (11.7%) were the least commonly seen sinonasal anatomic variants. Conclusion: Sinonasal anatomic variants are a rule rather than an exception, being present in a majority of population. These variations should be diagnosed and documented on CT examinations of paranasal sinuses to avoid any unforeseen complication during functional endoscopic sinus surgery and other skull base surgeries.
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The shoulder socket is called the glenoid fossa This socket is shallow and is part of the scapula (shoulder blade) The surface of the humeral head and the inside of the fossa are covered with articular cartilage The glenohumeral joint consists of an articulation between the scapula and humerus Retroversion angle of humeral head (or retrotorsion angle, RA) is an important parameter in total shoulder arthroplasty and is one of these important reference factors which can influence the outcomes of total shoulder arthroplasty This study was undertaken to evaluate the correlation between retroversion angle of humeral head and position of intertubercular sulcus The present study is a prospective one which was conducted in the Department of Radiodiagnosis and Imaging at Government Medical College and Hospital, Srinagar The 60 dry adult humeri were analyzed by multiplanar computed tomography (CT) CT data were transferred to a workstation (Silicon Grafics; Sunnyvale, CA) for multiplanar CT-reformation The mean retroversion angle of the humeral head in relation of the transe-picondylar axis was 123 degree The mean ITS orientation was 407 degree The Pearson correlation coefficient between the retroversion of the humeral head and the ITS orientation was -037 There was an inverse correlation between the retroversion of the humeral head and the ITS orientation This variation is due to several factors, including the definition of humeral head retroversion, different methods of measurement, ranges of normal values, and accuracy of anatomic landmarks to guide determination of anatomic retroversion Humeral head retroversion is generally defined with respect to the plane of the humeral head articular surface proximally; distally, however, Yassar Shiekh, Aamir Javed Khan, Mohammad Iqbal Bhat A CT scan anatomical study correlating between the retroversion of the humeral head and the orientation of the inter-tubercular sulcus IAIM, 2018; 5(12): 96-101 Page 97 the reference axis has been debated, including the transepicondylar axis, trochlear tangent axis and forearm axis The study concludes that there is a reverse correlation between the retroversion of the humeral head and the orientation of the intertubercular sulcus
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Background: acute myocardial infarction [MI] is a major health problem with a substantial mortality and morbidity. Numerous guidelines have been established that should be followed in the management of acute MI
Objective: to determine whether the current practice in managing patients admitted with acute MI in a tertiary care hospital is evidence based compliant
Patients and Methods: this retrospective study was based on the record of the patients with diagnosis ofMI admittedbetween January to June 2007, at Sheikh Zayed Hospital, Rahim Yar Khan, who fulfilled the predefined criteria
Results: Total number of cases were 58, mean age of the study subjects was 47+ 8.65 years, with age range of 16 to 95 years. It was observed that 81% of study subjects were male. Half of the patients belonged to lower income group; Laborer and house wives were 3 1 % and 19% respectively. Sixteen percent of patients were hypertensive and diabetic. 19 % were smoker and 5% had family history of coronary artery disease. Anterior and inferior wall MI were reported in 64% and 32% of the patients, respectively. Injection Streptokinase [SK] was given to 52% of the patients. Aspirin, clopidogril and nitrates were given to all patients, whereas 34 % and 36% were prescribed Beta blocker [BB] and statins, respectively. Angiotensin converting enzyme inhibitor [ACEI] was given in 43% patients
Conclusion: SK, the only means of acute revascularization was given in only 52% patients mainly due to delayed presentation. Use ofAspirin is an unbeatable target and given to all patients. Use of BB and statins in < 40% and ACEI in<50% is not optimal. However, these trends of cardiac medication in a tertiary care hospital with limited provision, reflects the diffusion of light of evidence based medicine into darkness of periphery